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. Author manuscript; available in PMC: 2014 Jun 25.
Published in final edited form as: Neuroscience. 2013 Mar 21;241:250–267. doi: 10.1016/j.neuroscience.2013.03.020

Figure 8. Figure Legend for the Graphic Art Abstract.

Figure 8

Food restriction (FR) evokes hyperactivity in some but not all of the adolescent female mice. Comparisons with control hippocampal tissue indicate that enlargement of GABAergic terminals onto the cell bodies of pyramidal neurons, together with the increased input throughout the dendritic tree, may contribute towards suppression of FR-evoked hyperactivity and resilience to food restriction. Conversely, the reduction of GABAergic inputs in SR may contribute towards the persistence of FR-evoked hyperactivity and severe weight loss. These findings indicate that the adolescent female mice can serve well as an animal model of anorexia nervosa (AN) and for exploring the cellular basis for the individual differences in vulnerability to AN.