Table 1. Concomitant and sequential sampling of GPs and PLGA nanoparticles by DN DCs.

GP-GP							GP-PLGA
Togethera				1 hr apart			Together			1 hr apart
	P1	P2	Both	P1	P2	Both	P1	P2	Both	P1	P2	Both
PP	65±3	64±6	62±6	43±8	53±3	40±6	39±1	39±0	39±1	47±6	52±5	41±6
MLN	90±2	91±2	90±2	43±7	52±4	42±4	70±4	73±2	70±3	35±4	38±2	35±2

^aP1, first particle; P2, second particle. Particles were administered to mice by gavage as a 1∶1 mixture (“together”) or serially “1 hr apart”. PP and MLN were collected 24 hr later, cryosectioned and viewed by confocal microscopy. Values indicate the average number (± standard deviation) of particle-containing DCs per PP, based on four mice per group and six sections per mouse.