. Author manuscript; available in PMC: 2015 Jan 21.

Published in final edited form as: Biochemistry. 2014 Jan 7;53(2):397–412. doi: 10.1021/bi401223r

Table 3.

Differential Preference of PTPs for Acidic over Neutral and Basic Sequences^a

enzyme	Acidic/Basic	Acidic/Neutral	Neutral/Basic
PEST	150000	1100	140
SHP1	100000	1800	57
SHP2	46000	370	120
PTPH1	2600	20	130
HePTP	2500	42	59
PTP1B	1500	24	61
PTPD2	1300	8	160
PTPRB	1100	14	77
TCPTP	910	17	53
PTPRC	880	22	41
PTPRO	660	37	18
PTPD1	220	330	0.7
PTPRD	21	21	1
PTPRA	2	3	0.5

Ratio of k_cat/K_M values for peptides Ac-YDEDFpYDYEF-NH₂ (acidic), Ac-SASASpYSASA-NH₂ (neutral), and Ac-YRKRFpYRYKF-NH₂ (basic).