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. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: Clin Cancer Res. 2013 Jun 6;19(14):3905–3913. doi: 10.1158/1078-0432.CCR-12-0287

Figure 2. A protracted KD increases radiation response in H292 lung cancer xenografts given conventional fractionated radiation.

Figure 2

H292 xenografts were grown in nude mice as in Figure 2. Mice (6-8 per group) were treated with KD for the entire treatment time and/or a 61.2 Gy total dose of radiation in 34 × 1.8 Gy fractions three times per week (M, W , F). The experiment was terminated 81 days after the beginning of KD. (A) Tumor growth curve estimates demonstrated that the KD significantly enhances radiation response as assayed by tumor growth rates (p=0.0210). (B) Pair wise group comparisons of Kaplan-Meir survival curves also demonstrated that the KD significantly enhanced radiation response (p=0.0041).