Skip to main content
. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: Clin Cancer Res. 2013 Jun 6;19(14):3905–3913. doi: 10.1158/1078-0432.CCR-12-0287

Figure 3. The responses of H292 and A549 lung cancer xenografts to hypo-fractionated radiation were enhanced by the KD.

Figure 3

H292 and A549 xenografts were grown in nude mice as in Figure 2. Mice (5-9 per group) were treated with KD for 2 days prior to radiation and continuing for a total of 7 days. Hypo-fractionated radiation (2 × 6 Gy fractions) was delivered on day 3 and 5 of the protocol. Tumor growth curves (A) and Kaplan-Meir survival plots (B) showed enhanced radiation responses in animals with H292 xenografts fed the KD (p<0.05), relative to IR alone. (C) Tumor volume growth curve estimates of A549 xenografts also demonstrated that KD + IR significantly slowed tumor growth when compared to radiation alone (p<0.05). All treatments were well-tolerated as demonstrated by the lack of weight loss during therapy (Supplemental Fig. 1A and B).