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. 2014 Mar 14;9(3):e90832. doi: 10.1371/journal.pone.0090832

Figure 6. Comparison of metabolic ratios.

Figure 6

Lactate production-to-glucose consumption ratio ((νf(LDH)-νr(LDH))/ν(HK)), pyruvate branch point as the ratio of the pyruvate influx through TCA cycle divided by the total flux into pyruvate pool (v(PDH/(ν(PK)+ν(SAL)+ν(ML-PC)+ν(AlaTA)), when the last two fluxes positively fed pyruvare, percentage of pyruvate derived from glucose ((v(PK)+ ν(PC))/(ν(PK)+ν(SAL)+ν(ML)+ν(AlaTA)), Contribution of glucose to TCA cycle as the ratio of pyruvate influx to TCA cycle via ν(PDH), considering most of the ν(PDH) has been originated from ν(PK), to the total flux channeled through TCA cycle via its intermediates (v(PDH)/(ν(PDH)+ ν(ASTA)+ ν(GLDH)+ ν(LYSILELEUVALTYRTA)+ν(PC)), Contribution of glutamine to TCA cycle as the ratio of glutamate influx to TCA cycle either via ν(GLDH) to the total flux channeled through TCA cycle via its intermediates (v(GLDH)/(ν(PDH)+ν(ASTA)+ν(GLDH)+ν(LYSILELEUVALTYRTA)+ν(PC))), contribution of other amino acids to TCA cycle ((v(LYSILELEUVALTYRTA)+ν(ASTA))/(ν(PDH)+ν(ASTA)+ν(GLDH)+ν(LYSILELEUVALTYRTA)+ν(PC))), ATP turnover rate (ν(PGK)+ν(PK)+v(SCOAS)+νr(GlnT)+ νf(CK)+vr(AK)+2P/O ratio*ν(resp)), percentage of ATP consumption for biomass synethesis(0.00043*3.78*ν(growth)/(v(LYSILELEUVALTYRTA)+ν(ASTA))/(ν(PDH)+ν(ASTA)+ν(GLDH)+ν(LYSILELEUVALTYRTA)+ν(PC)), and percentage of ATP consumption for antibodysynthesis(4*ν(mAb)/(v(LYSILELEUVALTYRTA)+ν(ASTA))/(ν(PDH)+ν(ASTA)+ν(GLDH)+ν(LYSILELEUVALTYRTA)+ν(PC)),between parental (solid line), induced low-producer (dashed line) and induced high-producer (dotted line) cell lines.