Table 1. Commonly deregulated genes in the three transgenic zebrafish liver cancer models.
Common | Gene Symbol | Human homolog Gene Symbol | xmrk | kras | Myc | ||||
FC | P value | FC | P value | FC | P value | ||||
Up | 18858688 | foxa3 | FOXA3 | 3.58 | 6.66E-03 | 1.78 | 4.16E-02 | 1.55 | 9.18E-03 |
18858728 | gart | GART | 3.32 | 1.42E-03 | 2.87 | 5.87E-03 | 7.69 | 6.93E-04 | |
18859502 | tp53 | TP53 | 5.09 | 1.43E-03 | 1.92 | 1.09E-02 | 3.61 | 3.30E-03 | |
41054118 | c20orf24 | C20orf24 | 4.92 | 2.13E-03 | 1.93 | 2.83E-03 | 3.14 | 5.22E-03 | |
41393080 | itm1 | STT3A | 1.98 | 7.59E-03 | 1.56 | 3.02E-02 | 2.01 | 8.07E-04 | |
47086630 | rhot1a | RHOT1 | 1.62 | 3.11E-02 | 1.87 | 3.00E-02 | 1.58 | 3.39E-02 | |
47087206 | abce1 | ABCE1 | 4.12 | 1.97E-03 | 6.79 | 1.25E-02 | 3.01 | 4.40E-03 | |
50344865 | cdkrap3 | CDK5RAP3 | 2.09 | 4.98E-03 | 1.85 | 2.06E-02 | 2.42 | 1.43E-03 | |
50345019 | mgat4b | MGAT4B | 4.09 | 1.62E-02 | 20.55 | 2.92E-02 | 1.70 | 3.03E-03 | |
50540209 | srprb | SRPRB | 1.85 | 2.00E-02 | 4.47 | 6.89E-04 | 2.65 | 5.84E-03 | |
55742596 | eif5a2 | EIF5A2 | 4.83 | 1.09E-03 | 1.45 | 4.07E-03 | 2.98 | 2.14E-04 | |
62955566 | cirbp | CIRBP | 6.11 | 1.63E-03 | 2.00 | 3.17E-02 | 2.16 | 1.44E-02 | |
66773145 | noc4l | NOC4L | 2.67 | 4.20E-02 | 1.63 | 3.58E-02 | 4.34 | 1.05E-02 | |
71834591 | reep2 | REEP2 | 4.38 | 3.51E-02 | 7.17 | 3.26E-03 | 8.38 | 7.95E-03 | |
76253887 | srp14 | SRP14 | 4.17 | 1.62E-03 | 1.71 | 1.61E-02 | 1.91 | 1.15E-04 | |
94536632 | stmn1a | STMN1 | 13.83 | 2.30E-03 | 3.05 | 4.93E-03 | 4.30 | 1.56E-02 | |
113679133 | mrps9 | MRPS9 | 1.71 | 2.85E-02 | 1.56 | 3.71E-02 | 2.40 | 1.59E-02 | |
121583749 | hmgcra | HMGCR | 7.42 | 5.42E-03 | 30.45 | 7.30E-04 | 8.71 | 2.41E-03 | |
126723627 | ubap2 | UBAP2 | 1.94 | 3.33E-02 | 1.88 | 4.99E-03 | 1.58 | 9.64E-03 | |
148225559 | fam162a | FAM162A | 2.15 | 2.76E-03 | 2.16 | 4.72E-02 | 1.97 | 2.22E-02 | |
169646807 | rrp9 | RRP9 | 4.20 | 1.01E-02 | 2.99 | 3.32E-02 | 2.71 | 3.48E-02 | |
Down | 23308680 | cyp2ad2 | – | 4.35 | 1.99E-02 | 9.09 | 8.07E-03 | 2.94 | 2.73E-02 |
41053663 | scp2 | SCP2 | 5.00 | 9.46E-03 | 2.94 | 2.02E-02 | 1.96 | 2.17E-02 | |
41055025 | hsd17b3 | HSD17B3 | 10.00 | 3.20E-02 | 100.00 | 7.61E-03 | 33.33 | 1.66E-02 | |
41152446 | hsdl2 | HSDL2 | 3.85 | 4.21E-02 | 2.13 | 3.55E-02 | 2.56 | 6.38E-03 | |
47085884 | fbp1b | FBP1 | 9.09 | 3.91E-04 | 8.33 | 1.86E-02 | 2.38 | 2.87E-02 | |
47086066 | tdh | TDH | 6.67 | 3.28E-02 | 2.86 | 1.50E-02 | 3.45 | 3.93E-02 | |
47086178 | itgb1b.2 | ITGB1 | 7.14 | 4.19E-02 | 7.14 | 6.40E-03 | 4.35 | 3.30E-03 | |
47086928 | ak3l1 | AK3L1 | 2.17 | 2.31E-02 | 10.00 | 1.56E-03 | 2.00 | 2.17E-02 | |
54400637 | ech1 | ECH1 | 1.52 | 2.29E-02 | 2.17 | 3.78E-03 | 2.00 | 1.51E-02 | |
55925455 | gpx4a | GPX4 | 3.57 | 6.79E-03 | 2.27 | 3.32E-02 | 5.26 | 7.31E-03 | |
56790261 | sod1 | SOD1 | 2.94 | 4.18E-02 | 1.85 | 5.32E-03 | 2.27 | 2.48E-02 | |
70778900 | slc27a2 | SLC27A2 | 9.09 | 3.26E-02 | 5.00 | 5.13E-03 | 2.78 | 1.08E-02 | |
71834285 | apobl | APOB | 5.26 | 4.21E-02 | 1.79 | 1.20E-02 | 1.75 | 1.46E-02 | |
71834671 | miox | MIOX | 3.13 | 3.05E-02 | 9.09 | 8.07E-03 | 4.55 | 4.30E-02 | |
121583789 | nrxn1b | NRXN1 | 4.76 | 4.87E-03 | 1.96 | 2.18E-02 | 6.67 | 1.51E-02 | |
148230211 | slco1d1 | – | 3.70 | 6.22E-03 | 4.17 | 1.00E-04 | 2.70 | 1.11E-03 |