Table 2. Degree of representation of the three transgenic zebrafish liver cancer signatures in human HCCs.
GEO accession | xmrk | kras | Myc | Total* | xmrk/kras | xmrk/Myc | kras/Myc | xmrk/kras/Myc | |
A | GSE364 | 12.6% | 17.2% | 19.5% | 31.0% | 8.0% | 6.9% | 6.9% | 3.4% |
B | GSE1898 | 9.9% | 11.0% | 16.5% | 22.0% | 8.8% | 7.7% | 7.7% | 6.6% |
C | GSE10141 | 28.8% | 25.0% | 17.5% | 46.3% | 16.3% | 7.5% | 5.0% | 3.8% |
D | GSE9843 | 35.2% | 23.1% | 25.3% | 54.9% | 14.3% | 9.9% | 8.8% | 4.4% |
E | GSE19977 | 37.8% | 21.3% | 25.0% | 45.1% | 20.1% | 18.9% | 13.4% | 13.4% |
F | GSE10186 | 32.2% | 27.1% | 12.7% | 44.9% | 19.5% | 5.1% | 6.8% | 4.2% |
G | GSE20017 | 44.4% | 23.7% | 30.4% | 50.4% | 23.0% | 24.4% | 17.8% | 17.0% |
H | GSE25097 | 34.7% | 31.0% | 34.7% | 60.4% | 20.1% | 14.9% | 15.3% | 10.4% |
I | GSE5975 | 26.9% | 32.4% | 32.4% | 46.2% | 22.3% | 17.2% | 21.4% | 15.5% |
J | GSE14520 | 30.5% | 20.0% | 20.5% | 47.6% | 11.4% | 10.0% | 6.2% | 3.3% |
Total | 29.2% | 23.5% | 23.8% | 47.2% | 16.9% | 12.5% | 11.5% | 8.8% |
Percentages indicate the percentages of human HCC samples which showed significant positive correlation (FDR<0.25) with the zebrafish liver cancer signatures.
*Total: The total percentage of human HCCs which showed significant correlation with any one or more of the zebrafish signatures.