The effect of radiation and JP4-039 on murine pregnancy at E17.5. Whole body irradiation at 0 Gy (sham) or 4 Gy (radiation) was performed on E13.5 as detailed in Methods. JP4-039 (10 mg/kg) was administered intravenously 10 min after radiation or sham. (A) Litter size, (B) fetal weight, (C) placenta weight, (D) maternal weight gain. Data were based on non-irradiated dams (n = 30, of which 8 received JP4-039), and irradiated dams (n = 17, of which 7 received JP4-039. *Denotes p < 0.05).