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. Author manuscript; available in PMC: 2014 Mar 14.
Published in final edited form as: Cancer Cell. 2012 Jul 10;22(1):106–116. doi: 10.1016/j.ccr.2012.05.015

Figure 2. FA Pathway Suppresses Genomic Instability upon Replication Stalling.

Figure 2

(A) Chromosomal aberrations measured by metaphase chromosome spreads with FANCA-deficient and –complemented GM6914 cells with HU (± SD, n = 40). Representative images of chromosomal aberrations of metaphase chromosomes are given. Scale bars (gray) correspond to 2 μm.

(B) Cell survival analysis of FANCA-defective, patient-derived GM6914 cells and cells complemented with FANCA upon continuous HU treatment (± SEM, n = 4).

(C) Cell survival analysis of FANCA-defective cells and cells complemented with FANCA upon continuous gemcitabine (GEM) treatment (± SEM, n = 3).

(D and E) Nascent tract length distribution curves measured by DNA spreading in patient-derived FANCA-defective GM6914 cells and cells complemented with the wild-type protein with gemcitabine [GEM, (D)] and camptothecin [CPT, (E)].

See also Figure S2.