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. Author manuscript; available in PMC: 2014 Mar 14.
Published in final edited form as: Med Res Rev. 2013 Apr 30;33(5):1119–1173. doi: 10.1002/med.21278

Figure 15.

Figure 15

(A) Chemical structure of the 8-ring pyrole–imidazole cyclic polyamide. (B) Overall structure (PDB ID: 3I5L) of the DNA duplex [d(CCAGGCCTGG)2] complexed with the Py-Im ligand (in the middle). (C) The hydrogen-bonding interactions between the Py/Im and G/C pair. (D) The hydrophobic packing between the O4′ atom and the amide ring systems. (E) The direct and water-mediated hydrogen-bonding interactions between the turn and the A/T pair.