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. Author manuscript; available in PMC: 2014 Mar 14.
Published in final edited form as: Med Res Rev. 2013 Apr 30;33(5):1119–1173. doi: 10.1002/med.21278

Figure 16.

Figure 16

(A) Chemical structure of the 8-ring pyrrole–imidazole cyclic polyamide. (B) Overall structure of the DNA duplex [d(5′-CCAGTACTGG-3′)2] complexed with the ligand (0.95 Å resolution and PDB ID: 3OMJ). (C) The hydrogen-bonding interactions between the Py/Py and A/T pair. (D) The direct and water-mediated hydrogen-bonding interactions between the turn and the A/T pair.