Table 2.
Change in CMRGlu in 4 regions of interest (right vs. left) at baseline, 3 months, and 12 months in responders and nonresponders.
| ROI | Group | Side | CMRGlu | Trend analyses | |||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
||||||||
| Baseline | 3 months | 12 months | F linear | P | F quadratic | P | |||
| ACC | Rsp | R | 5863 (287) | 5792 (233) | 5842 (285) | .15 | 0.71 | 8.59 | 0.019 |
| L | 5904 (261) | 5883 (242) | 5899 (298) | .01 | 0.94 | 0.65 | 0.44 | ||
| NRsp | R | 5951 (72) | 5929 (61) | 5911 (145) | .46 | 0.55 | 0.01 | 0.93 | |
| L | 6071 (53) | 6051 (73) | 6033 (140) | .39 | 0.58 | 0 | 0.98 | ||
| AIC | Rsp | R | 5635 (168) | 5561 (220) | 5622 (305) | .03 | 0.87 | 4.35 | 0.07 |
| L | 5699 (197) | 5742 (257) | 5753 (218) | .75 | 0.41 | 0.10 | 0.76 | ||
| NRsp | R | 5985 (82) | 5897 (80) | 5938 (104) | .71 | 0.46 | 5.53 | 0.10 | |
| L | 5909 (120) | 5863 (201) | 5884 (190) | .21 | 0.68 | 0.31 | 0.62 | ||
| DLPFC | Rsp | R | 6295 (214) | 6092 (237) | 6236 (278) | .68 | 0.44 | 13.44 | 0.006a |
| L | 6326 (189) | 6290 (202) | 6390 (327) | .49 | 0.50 | 1.49 | 0.26 | ||
| NRsp | R | 6145 (116) | 6153 (383) | 6123 (278) | .05 | 0.84 | 0.03 | 0.87 | |
| L | 6320 (144) | 6244 (254) | 6270 (183) | 1.00 | 0.39 | 0.34 | 0.60 | ||
| OFC | Rsp | R | 5916 (292) | 5825 (167) | 5944 (242) | .17 | 0.69 | 5.63 | 0.045 |
| L | 5978 (268) | 5964 (215) | 6032 (226) | .56 | 0.47 | 0.77 | 0.40 | ||
| NRsp | R | 5654 (267) | 5644 (324) | 5676 (299) | .28 | 0.63 | 0.09 | 0.78 | |
| L | 5740 (160) | 5715 (298) | 5704 (244) | .46 | 0.55 | 0.01 | 0.92 | ||
ACC = anterior cingulate cortex; AIC = anterior insular cortex; CMRGlu = mean cerebral metabolic rate for glucose; DLPFC = dorsolateral prefrontal cortex; NRsp = nonresponders (n = 4); OFC = orbitofrontal cortex; ROI = region of interest; Rsp = responders (n= 9).
All CMRGlu values are normalized to 5000 (see “Methods”).
a
Statistically significant at P= 0.0065.