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. Author manuscript; available in PMC: 2014 Mar 14.
Published in final edited form as: Oncogene. 2011 Dec 12;31(36):4012–4021. doi: 10.1038/onc.2011.569

Figure 6. Tissue microarray analysis demonstrates a correlation between Grb14 expression and human thyroid cancer invasiveness.

Figure 6

A tissue microarray (TMA) analysis of human thyroid carcinomas included 162 papillary thyroid carcinomas (PTC) and 41 follicular variant FV-PTC were stained for Grb14. A. Two representative papillary carcinomas exhibit markedly different staining for Grb14; the tumor on the left exhibited extra-thyroidal extension and multiple lymph node metastases, whereas the tumor on the right (B) was localized to thyroid. C. Image analysis confirmed a significant correlation between expression of the Grb14 adaptor and the presence of lymph node metastases (LNM). Comparisons were performed using the Wilcoxon rank sum test. The X-values represent the mean Grb14 staining intensity scores.