Figure 4. Mitochondrial Hyperfusion Induces Cell Death in addition to Cell Cycle Delay.

(A) Time-lapse images tracking U2OS_mitoEYFP for 18 hours following transfection of Drp1, Mff or control siRNAs. Individual cells were tracked throughout the time series to determine if they underwent mitotic cell division events (white arrows). (B) Graphical representation of the percentage of cells in each condition (at least 75 cells tracked for each condition) that underwent a mitotic cell division, underwent cell death (measured by cell retraction, nuclear condensation, and membrane blebbing) or underwent no event.