BCL11B, constitutively in the context of the NuRD repressor complex (NuRD), is subject to modification by kinases, phosphatases (PPTase), sumo-ligating enzymes (UBC9), sumo proteases (SENPx), and sumo-dependent ubiquitin-targeted ligases (StUBL) that alter its activity at the Id2 oncogene promoter over a 60 min time frame following mouse thymocyte stimulation. Termination of the stimulated signal involves ubiquitin-targeted degradation by the proteasome complex.