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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Trends Pharmacol Sci. 2013 Dec 30;35(2):76–85. doi: 10.1016/j.tips.2013.11.005

Figure 4. Sequential regulation of BCL11B by phosphorylation and sumoylation.

Figure 4

BCL11B, constitutively in the context of the NuRD repressor complex (NuRD), is subject to modification by kinases, phosphatases (PPTase), sumo-ligating enzymes (UBC9), sumo proteases (SENPx), and sumo-dependent ubiquitin-targeted ligases (StUBL) that alter its activity at the Id2 oncogene promoter over a 60 min time frame following mouse thymocyte stimulation. Termination of the stimulated signal involves ubiquitin-targeted degradation by the proteasome complex.