Table 3. Comparison of deduced amino acid sequences (specific positions) of Angolan HBV isolates and HBV/E consensus.
Consensus amino acids and positions | |||||||||||||||||||||||||||||||
Pre-S1 region | Pre-S2 region | S region | |||||||||||||||||||||||||||||
Samples | 34 | 38 | 56 | 66 | 76 | 84 | 85 | 90 | 5 | 11 | 16 | 17 | 18 | 19 | 22 | 39 | 3 | 10 | 13 | 14 | 20 | 21 | 45 | 83 | 129 | 164 | 189 | 193 | 195 | 203 | 204 |
R | R | K | F | W | L | K | D | S | A | R | V | R | G | F | A | S | G | L | V | F | L | A | F | Q | E | T | S | I | P | S | |
Concurrent HBsAg and anti-HBs | |||||||||||||||||||||||||||||||
LDA067 | . | . | . | . | . | . | . | N | . | . | . | . | K | . | . | . | G | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA072 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | V | . | . | . | . | . | . | . | . | . | . | I | . | . | . | . |
LDA111 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA232 | . | . | . | – | – | . | T | . | A | . | . | . | K | . | . | . | . | . | P | . | S | W | . | . | . | . | . | . | . | . | . |
LDA265 | K | . | E | . | . | . | T | . | . | . | . | . | . | . | – | . | . | . | . | . | . | . | . | . | H | . | . | . | . | . | . |
LDA277 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | N | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA278 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA423 | K | . | . | . | . | . | T | . | . | . | K | A | K | – | – | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA470 | . | . | . | . | S | . | . | N | . | . | K | – | – | – | – | . | . | E | R | . | . | S | . | . | . | . | . | . | . | . | . |
LDA481 | K | K | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | I | . | . | Q | N |
LDA489 | . | . | . | . | . | . | . | . | . | . | – | – | – | – | . | . | . | . | . | . | . | . | . | . | . | . | L | . | . | K | |
LDA494 | K | . | . | I | . | . | . | . | . | . | K | . | . | . | . | . | . | . | . | A | . | S | . | . | . | . | . | . | . | R | . |
HBsAg without anti-HBs | |||||||||||||||||||||||||||||||
LDA154 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA173 | . | . | . | V | . | . | . | . | . | . | . | . | . | . | . | V | . | . | . | . | . | . | . | . | . | G | . | . | M | . | . |
LDA264 | . | K | . | V | . | . | . | . | Y | T | . | . | . | . | S | . | . | K | . | . | . | . | . | . | . | . | I | . | . | . | . |
LDA274 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | G | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA332 | . | . | . | . | . | . | . | N | . | . | . | . | . | D | L | . | . | . | . | . | . | . | . | . | . | G | . | . | . | . | . |
LDA335 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA339 | . | . | . | . | . | . | T | . | . | . | . | . | . | . | L | . | . | . | . | . | . | . | . | . | H | D | . | L | M | . | . |
LDA379 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | S | . | . | . | . | . | . | . | . |
LDA349 | . | . | . | . | * | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA386 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA399 | . | K | . | . | . | . | . | . | . | . | . | . | . | . | . | . | N | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA405 | . | . | . | . | . | Q | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | V | . | . | . | . | . | . | . | . |
LDA408 | . | K | Q | . | . | . | . | N | . | . | . | . | . | . | . | . | . | . | . | A | S | . | . | C | . | G | I | . | . | . | . |
LDA417 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | L | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA439 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | G | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA445 | . | . | . | . | . | Q | . | . | . | . | . | . | . | . | . | . | G | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
LDA452 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | N | . | . | . | . | . | . | C | . | . | . | . | . | . | . |
LDA504 | . | . | . | . | . | . | . | . | . | T | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
Consensus sequence shown at the top of the table was deduced from the HBV/E full-length sequences available in GenBank. Only positions for which at least two, but not all, Angolan isolates showed differences with the consensus sequence, are shown.
–: deletion; *: stop codon.