Figure 3. Changes in extracellular dopamine concentration in NAcc shell during anticipation and consumption of food in FR rats: modulation by CB1 receptor ligands.

Rats were trained to consume their daily meal during a 2-h period, and microdialysis samples were collected from the NAcc shell before, during, and after food presentation. Animals received an acute administration of vehicle (closed cycles; n = 5), WIN 55,212-2 (5 mg/kg, i.p., open triangles; n = 4), or a combination of WIN 55, 212-2 (5 mg/kg, i.p.) and SR141716 (1 mg/kg, i.p.)(open squares; n = 6) at 40 min before food presentation. Data are expressed as a percentage of basal values and are means ± SEM. ^a P<0.05, ^a’ P<0.01 versus basal values; ^b P<0.01 versus corresponding vehicle value.