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. 2014 Mar 14;9(3):e92224. doi: 10.1371/journal.pone.0092224

Figure 9. Effects of the systemic administration of SR141716 in fed ad libitum and FR rats on mPFC and VTA neurons excitability and inhibitory activity of WIN 55212-2 and baclofen on sIPSC frequency in mPFC neurons.

Figure 9

SR141716 (1 mg/kg, i.p.) was administered 1 h before sacrifice; for FR rats, sacrifice corresponded to the 5 min preceding food consumption. (A) Bar graph representing the effect of the administration of SR141716 on spontaneous AP firing recorded in VTA dopaminergic neurons. Data are expressed as absolute values (Hz) and were obtained from 3 different cells for each experimental group. (B) Bar graph representing the effect of SR141716 on the frequency of depolarization-induced APs in mPFC neurons. Data are expressed as absolute values (Hz) and were obtained from 4 to 9 different cells for each experimental groups. (C, D) Bar graphs representing the effect of SR141716 on the inhibitory action of (C) WIN 55212-2 (5 µM) and (D) baclofen (10 µM) on sIPSC frequency in mPFC neurons. Data are expressed as percentage of control and were calculated from 4 to 6 different cells. a P<0.0001 versus fed ad libitum rats treated with vehicle; b P<0.0001 versus FR treated with vehicle. For all experiments one way ANOVA and Newman Keuls post hoc test were performed.