Table 4. Stratification analysis of the combined genotypes of the PTEN, AKT1, MDM2 and p53 polymorphisms and risk of nasopharyngeal carcinoma.
| Variables | Cases, n (%) | Controls, n (%) | P a | OR (95% CI)a | P Homogeneity b | ||
| Low-risk groupc | High-risk groupc | Low-risk groupc | High-risk groupc | ||||
| Sex | |||||||
| Male | 38 (10.1) | 337 (89.9) | 57 (15.7) | 307 (84.3) | 0.026 | 1.65 (1.06–2.58) | 0.85 |
| Female | 10 (6.8) | 138 (93.2) | 11 (12.5) | 77 (87.5) | 0.31 | 1.64 (0.62–4.32) | |
| Age (year) | 0.62 | ||||||
| ≤ 47 | 22 (8.1) | 250 (91.9) | 23 (10.8) | 191 (89.2) | 0.46 | 1.28 (0.66–2.47) | |
| > 47 | 26 (10.4) | 225 (89.6) | 45 (18.9) | 193 (81.1) | 0.01 | 1.97 (1.16–3.33) | |
| Smoking status | 0.97 | ||||||
| Nonsmoker | 32 (8.9) | 328 (91.1) | 46 (15.1) | 259 (84.9) | 0.036 | 1.68 (1.03–2.73) | |
| Smoker | 16 (9.8) | 147 (90.2) | 22 (15) | 125 (85) | 0.12 | 1.81 (0.86–3.81) | |
| Drinking status | 0.57 | ||||||
| Nondrinker | 28 (8.8) | 290 (91.2) | 44 (13.9) | 273 (86.1) | 0.072 | 1.60 (0.96–2.69) | |
| Drinker | 20 (9.8) | 185 (90.2) | 24 (17.8) | 111 (82.2) | 0.06 | 1.90 (0.97–3.71) | |
| Smoking level (pack-years) | 0.36 | ||||||
| ≤ 19 | 5 (9.1) | 50 (90.9) | 11 (12.9) | 74 (87.1) | 0.34 | 1.83 (0.53–6.36) | |
| > 19 | 11 (10.2) | 97 (89.8) | 11 (17.7) | 51 (82.3) | 0.15 | 2.03 (0.78–5.31) | |
| Nationality | 0.71 | ||||||
| Han | 33 (8.9) | 338 (91.1) | 51 (15.3) | 283 (84.7) | 0.008 | 1.90 (1.17–3.07) | |
| Non-Han | 15 (9.9) | 137 (90.1) | 17 (14.4) | 101 (85.6) | 0.61 | 1.25 (0.53–2.90) | |
Abbreviations: OR, odds ratio; CI, confidence interval.
a
ORs and P values were calculated by multivariate logistic regression, adjusted for age, sex, smoking and drinking status, smoking level and nationality when appropriate within the strata.
b
For differences in ORs within each stratum.
c
Low-risk group, individuals carrying 0–2 risk genotypes; high-risk group, individuals carrying 3–4 risk genotypes.