Scheme 1.

Original synthesis of IRES-binding 5.^a,90

^a Reagents: (a) NaH, diethyl malonate, THF; (b) LiAlH₄, THF; (c) acetyl chloride, DCM, TEA, DMAP; (d) HNO₃; (e) 9, DCM, CaCO₃; (f) DMSO, MeOH, K₂CO₃; (g) Pd/C, H₂, MeOH; (h) BzNCS, DIPEA, DCM; (i) EDC, DCM; (j) HCl, dioxane; (k) mesyl chloride, TEA, DMAP, DCM; (l) Me₂NH/H₂O, DMF.