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. Author manuscript; available in PMC: 2015 Mar 13.
Published in final edited form as: J Med Chem. 2013 Nov 6;57(5):1952–1963. doi: 10.1021/jm401362f

Scheme 1.

Scheme 1

Synthesis of Target Compounds 3–10a

aReagents and conditions: i) BnNH2, Et2O/EtOH 4:1, rt; ii) K2CO3, dry DMF, 80 °C; iii) 8 N HCl, MW, 120 °C, 15 bar; iv) BnCl, K2CO3, DMF, 60 °C; v) piperazines, Et3N, MeCN, 80 °C; vi) aqueous NaCl 3.5%, Fe-powder, DMF, reflux.