Skip to main content
. Author manuscript; available in PMC: 2015 Mar 13.
Published in final edited form as: J Med Chem. 2013 Nov 6;57(5):1952–1963. doi: 10.1021/jm401362f

Scheme 2.

Scheme 2

Alternative Synthesis of Target Compound 8a

aReagents and conditions: i) Arylpiperazines, DMF, 80 °C; ii) H2, Raney-Ni, DMF, rt, atm pressure; iii) aqueous NaOH 5%, EtOH 1:1, reflux; iv) BnCl, K2CO3, DMF, 60 °C.