Fig 3.

Dose response curves for the antinociceptive effects of opioid-related ligands against acute thermal nociception and effect on scratching behavior. Results are expressed as % maximum possible effect for each agonist against acute thermal stimulus at 50 °C (large panels) and number of scratches observed (enclosed panels). Open symbols represent the treatment with agonist alone. Closed symbols represent pretreatment with single dose of naltrexone 0.01 mg/kg, nor-binaltorphimine 3 mg/kg or J-113397 0.03 mg/kg for corresponding agonists. Each value represents mean ± S.E.M (n=4). *significant difference from baseline scratching responses (p<0.05)