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Mean (±SEM) percent maximal control ICSS response rate following 20 minute of exposure to nitrous oxide gas combined with 100% oxygen. Closed symbols represent the nitrous oxide treatment condition and open symbols the air control condition. (a) 20% nitrous oxide (b) 40% nitrous oxide (c) 60% nitrous oxide (d) 80% nitrous oxide. * denotes significant differences compared to saline control (p < 0.05).
