. Author manuscript; available in PMC: 2015 Mar 13.

Published in final edited form as: J Med Chem. 2013 Nov 6;57(5):1914–1931. doi: 10.1021/jm401329s

Table 1.

Bicyclic Core Templates with Replicon (GT-1a and GT-1b) Data.

compd	GT-1a EC₅₀ (nM)^a	GT-1b EC₅₀ (nM)^a
7	8.0	3.0
33	3.8	3.5
34	25	16
35	7.2	3.2
36	4	1
37	83	12
38	17	NA

EC₅₀ measured using stable HCV (GT-1a H77, GT-1b Con1) subgenomic replicon assay (n ≥ 2).