Table 2.

Different Head Groups on the 3,5,6,8-Tetrasubstituted Quinoline Core with Replicon (GT-1a and GT-1b) Data.

compd	R	GT-1a EC50 (nM)a	GT-1b EC50 (nM)a
35		7.2	3.2
39		5.2	3.1
40		4.2	2.0
41		1.1	1.0
42		4.6	3.2
43		64	20
44		3.0	1.5

^aEC₅₀ measured using stable HCV (GT-1a H77, GT-1b Con1) subgenomic replicon assay (n ≥ 2).