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Pharmacokinetic parameters for 41 in rat and dog.
| species |
iv
|
po
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| dosea | Cl (mL/min/kg) | Vdss (L/kg) | t1/2 (h) | dosea,b | Cmax (μg/mL) | C at 8 h (μg/mL) | AUC(inf) (μg•h/mL) | F% | |
| rat | 2.6 | 11.4 | 2.2 | 4.3 | 30 | 2.1 | 0.62 | 13.8 | 26 |
| dog | 0.86 | 7.5 | 2.8 | 4.3 | 30 | 1.5 | 0.99 | 23.7 | 31 |
Dose in mg/kg, 20% PEG400, n = 3.
Amorphous MBP, n = 3.
