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. Author manuscript; available in PMC: 2015 Mar 13.
Published in final edited form as: J Med Chem. 2013 Nov 6;57(5):1914–1931. doi: 10.1021/jm401329s

Table 8.

Pharmacokinetic parameters for 50 in rata and dog.b

species iv
po
dosea Cl (mL/min/kg) Vdss (L/kg) t1/2 (h) dosea,b Cmax (μg/mL) C at 8 h (μg/mL) AUC(inf) (μg•h/mL) F%
rat 3.0 13.8 2.3 5.6 30 3.8 1.79 37.0 100
dog 1.0 4.4 1.5 5.1 3 0.36 0.21 4.2 36
a

Dose in mg/kg, 20% PEG400, n = 3.

b

Aqueous suspension, n = 3.