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. 2013 Dec 2;13(2):360–366. doi: 10.1111/acel.12180

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© 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Distribution of dmCpG. Log(2) ratio of observed [fraction of dmCpG from all CpG sites on the microarrays (aCpG) in a region] to expected (fraction of dmCpG from aCpG in genome) for a region. Black color indicates a significant overrepresentation (P < 0.05) of dmCpG. The positional categories of dmCpG contain the location of dmCpG sites in relation to specific sequence features in the genome. The number following TSS/TES refers to the number of nucleotides upstream and downstream of TSS/TES. A detailed regional description and the breakdown of the hyper- and hypomethylated site observed/expected ratios can be found in Table S12 (Supporting Information) and Table S2.