Table 2.

Genes set enrichment analysis

NAME	Source	NES	NOM p-val	FDR q-val	FWER p-val
NOD-like receptor signaling pathway	KEGG	2.443	<0.001	<0.001	<0.001
TOLL-like receptor signaling pathway	KEGG	2.222	<0.001	<0.001	<0.001
IL 1R pathway	BIOCARTA	2.19	<0.001	0.0003	0.001
MYD88 cascade	REACTOME	2.161	<0.001	0.0002	0.001
NTHI pathway	BIOCARTA	2.157	<0.001	0.0002	0.001
Activated TLR4 signaling	REACTOME	2.103	<0.001	0.0014	0.008
TLR9 cascade	REACTOME	2.066	<0.001	0.0026	0.018
TOLL pathway	BIOCARTA	2.064	<0.001	0.0023	0.018

NES, normalized enrichment score (accounts for differences in gene set size and in correlations between gene sets and the expression dataset to allow for comparisons across gene sets); NOM p-val, nominal p value (estimates the statistical significance of the enrichment score for a single gene set); FDR, false discovery rate (estimated probability that a gene set with a given NES represents a false positive finding); FWER, familywise-error rate (conservative correction that seeks to ensure that the list of reported results does not include even a single false-positive gene set). [7]