Table 2.
NAME | Source | NES | NOM p-val | FDR q-val | FWER p-val |
---|---|---|---|---|---|
NOD-like receptor signaling pathway | KEGG | 2.443 | <0.001 | <0.001 | <0.001 |
TOLL-like receptor signaling pathway | KEGG | 2.222 | <0.001 | <0.001 | <0.001 |
IL 1R pathway | BIOCARTA | 2.19 | <0.001 | 0.0003 | 0.001 |
MYD88 cascade | REACTOME | 2.161 | <0.001 | 0.0002 | 0.001 |
NTHI pathway | BIOCARTA | 2.157 | <0.001 | 0.0002 | 0.001 |
Activated TLR4 signaling | REACTOME | 2.103 | <0.001 | 0.0014 | 0.008 |
TLR9 cascade | REACTOME | 2.066 | <0.001 | 0.0026 | 0.018 |
TOLL pathway | BIOCARTA | 2.064 | <0.001 | 0.0023 | 0.018 |
NES, normalized enrichment score (accounts for differences in gene set size and in correlations between gene sets and the expression dataset to allow for comparisons across gene sets); NOM p-val, nominal p value (estimates the statistical significance of the enrichment score for a single gene set); FDR, false discovery rate (estimated probability that a gene set with a given NES represents a false positive finding); FWER, familywise-error rate (conservative correction that seeks to ensure that the list of reported results does not include even a single false-positive gene set). [7]