Table 3.

Significantly enriched transcripts in GSEA pathways

NLR signaling pathway		TLR signaling pathway		IL1R pathway		MYD88 cascade		NTHI pathway		Actvated ILR4 signaling		TLR9 cascade		TOLL pathway
IL1B	1.162	IL1B	1.162	IL1B	1.162	TLR6	0.805	IL1B	1.162	TLR6	0.805	TLR6	0.805	TLR6	0.805
NLRP3	1.135	IL6	0.931	IL1A	0.952	TLR1	0.796	NFKB1	0.629	TLR1	0.796	TLR1	0.796	TLR4	0.677
IL6	0.931	CCL4	0.842	IL6	0.931	TLR4	0.677	TLR2	0.608	TLR4	0.677	TLR4	0.677	NFKB1	0.629
TNFAIP3	0.792	TLR6	0.805	IL1RN	0.676	IRAK3	0.636	MAPK14	0.602	IRAK3	0.636	IRAK3	0.636	TLR2	0.608
MEFV	0.632	TLR1	0.796	IL1RAP	0.673	TLR2	0.608	IL8	0.558	TLR2	0.608	TLR2	0.608	MAPK14	0.602
NFKB1	0.629	TLR4	0.677	IRAK3	0.636	TLR8	0.453	MAP2K6	0.542	TLR8	0.453	TLR8	0.453	MAP2K6	0.542
NAIP	0.613	NFKB1	0.629	NFKB1	0.629	TLR10	0.406	TNF	0.360	TLRI0	0.406	TLR10	0.406	TLR10	0.406
MAPK14	0.602	TLR2	0.608	MAPK14	0.602	TLR5	0.345	NFKBIA	0.309	TLR5	0.345	TLR5	0.345	PGLYRP1	0.358
NLRC4	0.565	MAPK14	0.602	MAP2K6	0.542	IRAK4	0.341	CREBBP	0.25B	IRAK4	0.341	IRAK4	0.341	FOS	0.336
IL8	0.558	CCL3	0.583	IL1R1	0.411	LY96	0.259	IKBKB	0.23B	TBK1	0.320	LY96	0.259	NFKBIA	0.309
CXCL1	0.539	IL8	0.558	IRAK2	0.410			DUSP 1	0.229	LY96	0.259	PIK3C3	0.248	EIF2AK2	0.282
CXCL2	0.524	MAP2K6	0.542	TNF	0.360			SMAD3	0.214					LY96	0.259
CASP5	0.518	PIK3CG	0.464	NFKBIA	0.309									IKBKB	0.238
CARD8	0.413	TLR8	0.453											CD14	0.200
CCL7	0.413	TNF	0.360
CASP1	0.394	TLR5	0.345
BIRC2	0.394	IRAK4	0.341
TNF	0.360	FOS	0.336
BIRC3	0.358	IFNAR1	0.321
NFKBIA	0.309	TBK1	0.320
CASP8	0.299	NFKBIA	0.309
IKBKB	0.238	CASP8	0.299
MAPK10	0.218	LY96	0.259
CCL2	0.199	RAC1	0.258
ERBB2IP	0.196	STAT1	0.254
XIAP	0.189	PIK3CA	0.240
NOD2	0.187	IKBKB	0.238
MAPK11	0.170	PIK3CD	0.232
CCL11	0.164	MAPK10	0.218
		PIK3R5	0.200
		CD14	0.200

Numbers represent the rank metric score of each gene which is used to position the gene in the ranked list. The ranking metric measures an individual transcript’s correlation with the PGD phenotype.