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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Virology. 2014 Jan 29;0:86–94. doi: 10.1016/j.virol.2013.12.038

Figure 4. Localization of the HVP2 murine neurovirulence determinant.

Figure 4

The general layout of the HVP2 genome and genes in the right half of the UL region are shown at top. The parental origin of sequences in all nine recombinants that had a second recombination site between UL33 and UL51 was determined by sequencing of PCR products generated at approximately 5 kb intervals (indicated by triangles). Sequences from the neurovirulent parent virus are indicated by black and those from the apathogenic parent virus by white; gray areas represent areas between PCR points in which the second recombination point lies. The neurovirulence phenotype of each virus is indicated at right. For all nine recombinants, the parental origin of the region of the HVP2 genome between the ends of the UL36 and UL40 genes correlates with the neurovirulence phenotype.