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. Author manuscript; available in PMC: 2015 Mar 5.
Published in final edited form as: Neuron. 2014 Mar 5;81(5):1111–1125. doi: 10.1016/j.neuron.2014.01.012

Figure 6. Persistent mAChR Activity Drives Ca2+ - and DAGL-Dependent eCB Release.

Figure 6

(A) Diagram of experimental design. (B–C) Representative cells and group data showing that in the continuous presence of Oxo-M, SR141716 causes synaptic potentiation relative to vehicle conditions. (C) Co-incubation of THL and Oxo-M prevents SR141716-induced synaptic potentiation, as does intracellular BAPTA loading. (D) Summary data showing the effects of SR141716 under vehicle, Oxo-M, Oxo-M+THL, and Oxo-M+BAPTA pre-treatment conditions. (E) Representative traces of summary data in (D). ***p<0.001, ****p<0.0001. Scale bars: 10ms, 100pA. Data presented as mean ± SEM.