(A) Diagram of experimental design. (B–C) Representative cells and group data showing that in the continuous presence of Oxo-M, SR141716 causes synaptic potentiation relative to vehicle conditions. (C) Co-incubation of THL and Oxo-M prevents SR141716-induced synaptic potentiation, as does intracellular BAPTA loading. (D) Summary data showing the effects of SR141716 under vehicle, Oxo-M, Oxo-M+THL, and Oxo-M+BAPTA pre-treatment conditions. (E) Representative traces of summary data in (D). ***p<0.001, ****p<0.0001. Scale bars: 10ms, 100pA. Data presented as mean ± SEM.