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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: J Glaucoma. 2013 Jun-Jul;22(0 5):S36–S38. doi: 10.1097/IJG.0b013e3182934af6

FIGURE 1.

FIGURE 1

Conformational changes of Alzheimer’s amyloid-β protein and their relationship with disease pathogenesis. The diagram illustrates the transition from soluble monomeric species found under normal physiological conditions to fibrillar components deposited in Alzheimer’s disease in the form of neuritic plaques and vascular amyloid. Intermediate conformations composed of oligomeric assemblies and/or protofibrillar elements lead – through the crosstalk of a number of downstream pathways – to cell injury, synaptic pathology, and cognitive impairment.