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. Author manuscript; available in PMC: 2014 Sep 18.
Published in final edited form as: J Am Chem Soc. 2013 Sep 5;135(37):13885–13891. doi: 10.1021/ja4059525

Figure 5.

Figure 5

Site-dependent cell internalization and RNA silencing for A121-IgG-P1 and Q389-IgG-P1. (A–B), Confocal microscopy of FITC-siRNA delivered to SKBR-3 cells by A121-IgG-P1 (A) and Q389-IgG-P1 (B). (C) CYBR-Green qRT-PCR analysis of gene silencing at the mRNA level in HER2+ and HER2 cells ; the results showed that the Q389-IgG-P1/GAPDH-siRNA complex reduces relative GAPDH mRNA levels in SKBR-3 (blue), but not NIH-3T3 (red) and HeLa (green) cells.