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. Author manuscript; available in PMC: 2014 Mar 15.
Published in final edited form as: Transl Gastrointest Cancer. 2012 Oct;1(3):215–227.

Figure 1.

Figure 1

A. Macroscopic appearance of colorectal tumors from wild type and Hdc–/– mice. Hdc–/– mice and wild type mice (both male Balb/c background) were injected with a single dose of AOM followed by DSS in the drinking water for 10 days. Fifteen weeks post DSS treatment more large colonic tumors were observed in the distal colon and rectum of Hdc–/– mice; B. The number of large and small colorectal tumors in Hdc–/– mice versus wild type mice (*P<0.05; Mean ± SD. n=8, each group); C. Representative hematoxylin-eosin stained colonic tumor sections from wild type and Hdc–/– mice (Scale bar, 50 μm). Reprinted with permission from Yang et al., Nature Medicine 2011; 17(1):87-95