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. Author manuscript; available in PMC: 2014 Mar 15.
Published in final edited form as: Transl Gastrointest Cancer. 2012 Oct;1(3):215–227.

Figure 3.

Figure 3

After HDC knockdown in cholangiocarcinoma cells (Mz-HDC), xenograft tumor development was significantly inhibited when compared to the tumors containing normal levels of HDC (Mz-neg). Further, in tumor sections extracted from the animal model (that contain 99% cholangiocarcinoma cells), both proliferating cellular nuclear antigen and HDC expression were significantly decreased in the HDC knockdown transfected tumors (Mz-HDC). (Reprinted with permission from Francis et al. Gut, 2012;61:753-64.)