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. Author manuscript; available in PMC: 2014 Mar 15.
Published in final edited form as: Science. 2011 Feb 4;331(6017):550–553. doi: 10.1126/science.1191138

Figure 2.

Figure 2

Model for miRNA-mediated silencing. Cartoon outlines the proposed streamlined model, beginning with recruitment of Argonaute and associated GW182 and involving potential interactions with mRNA m7G cap. These binding events ultimately lead to translational repression by blocking some early step in translation initiation. Deadenylation by CCR4:NOT1 may contribute to translational repression at an initial step. Lastly, after deadenylation, miRNA targeted mRNA may be subjected to degradation (consolidation) through recruitment of decapping complex (DCP1/2).