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. 2014 Jan 16;18(3):415–421. doi: 10.1111/jcmm.12218

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© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effects of Cardiac miR-133 overexpression on fibrosis regulators during diabetes. Whole heart tissue from animals that had been diabetic for 2 months was analysed for mRNA levels of fibronectin (FN1; A), collagen (COL4A1; B), fibroblast growth factor1 (C), transforming growth factor-β1 (D) and connective tissue growth factor (E). Diabetes-induced up-regulation of these transcripts was prevented in the miR-133a animals. Expression data were normalized to that of the reference gene, 18S. n = 6–8/group; values are mean ± SEM. *Significantly different from ntg group, #significantly different from ntg/D group, P < 0.05.