Table 1.
Cytokine content in lungs or BAL
| PGD2† (ng/μg) | TNF-α (ng/μg) | IL-1β (pg/μg) | IL-5 (pg/μg) | IL-6 (ng/μg) | IL-18 (pg/μg) | |
|---|---|---|---|---|---|---|
| Naive | 5.6 ± 0.2 | 6.6 ± 0.6 | 1.5 ± 0.06 | 3.9 ± 0.3 | 3.6 ± 0.1 | 1.9 ± 0.2 |
| Sensitized | 5.8 ± 0.3 | 6.5 ± 0.4 | 1.7 ± 0.05 | – | – | – |
| Vehicle | 34.1 ± 2.6* | 24.7 ± 2.2* | 6.7 ± 0.4* | 4.9 ± 0.2* | 9.3 ± 0.7* | 11.2 ± 0.5* |
| HYDAMTIQ 1 mg/Kg | 22 ± 2.2** | 21.1 ± 1.9 | 5.2 ± 1.3** | 3.4 ± 0.2** | 6.4 ± 0.7** | 8.4 ± 0.3** |
| HYDAMTIQ 3 mg/Kg | 20.1 ± 1.3*** | 15.5 ± 1.7*** | 4.9 ± 0.5** | 3.5 ± 0.07** | 7.5 ± 1.1** | 8.4 ± 0.6** |
| HYDAMTIQ 10 mg/Kg | 8.3 ± 0.6*** | 11.1 ± 0.6*** | 2.8 ± 0.2*** | 1.8 ± 0.1*** | 5.1 ± 0.3*** | 4.9 ± 0.6*** |
†
PGD2 was measured in BAL supernatant. TNFα, IL-1β, IL-5, IL-6 and IL-18 in the supernatant of lung homogenates. “-”: not determined. The values are expressed as ng or pg of protein/μg of total proteins. Values are means ± SEM.
***
P < 0.01 and
**
P < 0.05 versus Vehicle
*
P < 0.01 versus Naive.