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. Author manuscript; available in PMC: 2014 Mar 15.
Published in final edited form as: Curr Top Med Chem. 2012;12(22):2623–2640. doi: 10.2174/1568026611212220014

Fig. 1.

Fig. 1

Pathways and modifiers influencing proteostasis. Genetic, epigenetic, physiological and environmental stressors affect proteostasis and cause the accumulation of misfunctional proteins. Small molecule modulators of the activities of the proteostasis network pathways (small molecule proteostasis regulators) facilitate chaperone-mediate refolding and/or induce the degradation of misfolded and damaged proteins therefore rebalancing cellular proteostasis. In parenthesis are indicated some of the genes responsible for proteostasis maintenance.