Table 4. Toxic effects associated with adjuvant chemotherapy.
| Paclitaxel group (n=40) | Fluorouracil group (n=41) | |||||||
|---|---|---|---|---|---|---|---|---|
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
| Auditory or hearing | 1 | 2 | 1 | 0 | 1 | 0 | 0 | 0 |
| Blood or bone marrow | 5 | 3 | 20 | 9 | 2 | 5 | 15 | 12 |
| Cardiovascular (arrhythmia) | 1 | 1 | 1 | 0 | 2 | 1 | 0 | 0 |
| Cardiovascular (general) | 3 | 1 | 1 | 1 | 5 | 3 | 1 | 0 |
| Constitutional symptoms | 18 | 13 | 1 | 0 | 9 | 13 | 8 | 0 |
| Dermatological or skin | 11 | 5 | 0 | 0 | 5 | 5 | 1 | 0 |
| Endocrine | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Gastrointestinal | 16 | 8 | 1 | 0 | 13 | 10 | 1 | 0 |
| Haemorrhage | 3 | 0 | 3 | 0 | 2 | 1 | 1 | 0 |
| Hepatic | 9 | 3 | 2 | 0 | 13 | 6 | 0 | 0 |
| Infection febrile neutropenia | 0 | 2 | 3 | 1 | 1 | 2 | 4 | 2 |
| Lymphatics | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Metabolic or laboratory | 3 | 9 | 10 | 1 | 8 | 8 | 9 | 2 |
| Musculoskeletal | 1 | 1 | 0 | 0 | 3 | 3 | 0 | 0 |
| Neurology | 15 | 1 | 2 | 1 | 10 | 5 | 2 | 0 |
| Ocular or visual | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Other | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Pain | 9 | 3 | 0 | 0 | 8 | 5 | 0 | 0 |
| Pulmonary | 10 | 4 | 1 | 0 | 7 | 4 | 2 | 0 |
| Renal or genitourinary | 17 | 4 | 2 | 0 | 14 | 7 | 0 | 0 |
| Sexual or reproductive function | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
No grade 5 toxic effects were reported. Patients could report >1 adverse event (graded according to Common Terminology Criteria for Adverse Events, version 2.0).