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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: J Allergy Clin Immunol. 2013 Mar 28;131(5):1443–6.e1. doi: 10.1016/j.jaci.2013.02.026

Figure 2. HCQ treatment preferentially induces apoptosis in CD4+CD45RA-CD45RO+ T cells.

Figure 2

(A) Apoptosis (by Annexin V staining) in human CD4+ cells, cultured in the presence of HCQ, n=8. (B) Histograms of (A). (C) Apoptosis in human CD4+CD45RA+CD45RO- and CD4+CD45RA-CD45RO+ cells, n=7. (D) FACS-plot of HCQ treated CD4+CD45RA+CD45RO- (blue) and CD4+CD45RA-CD45RO+ (red) cells stained with propidium iodide (PI). (E+F) Sorted CD4+CD45RA+ (CFSE) or CD4+CD45RO+ (EF670) cells were mixed at a 1:1 ratio and cultured in the presence of HCQ, (n=4).