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The effect of naloxone (10–5 M) on inhibition of C3 production by morphine (10–3 M) in rat astrocytes.
| TNF-α (5 U/ml) Only (baseline) | TNF-α (5 U/mL) + Morphine (10–3 M) | Naloxone + TNF-α (5 U/mL) and Morphine (10–3 M) | |
|---|---|---|---|
| 100 | C3 production (%) | 33⁎ | 52† |
TNF-α = tumor necrosis factor-α.
Values are mean percent C3 production.
P < 0.05 compared with cells stimulated with TNF-α (5 U/ml) only.
P < 0.05 compared with cells incubated with TNF-α (5 U/mL) and morphine (10–3 M).
