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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Nucl Med. 2013 Jul 19;54(9):1621–1629. doi: 10.2967/jnumed.112.118539

Figure 1.

Figure 1

Effect of cisplatin on nuclear uptake of 64Cu in p53 wild-type and null HCT116 cell lines. HCT116 cells were incubated with or without 40 μM cisplatin before incubation with 64Cu-acetate (A) or 64Cu-DOTA-cetuximab (B) for another 20 h. (C) Expression level of p53 in HCT116 cells cultured with 64Cu-DOTA-cetuximab, either with or without prior incubation with cisplatin, was detected by Western blot. Amount of p53 detected in both whole cells and pure nuclei are shown.