Fig. 2. In vitro eight-point dose-response curves for clomiphene evaluated against native filovirus strains, EBOV/Kik (EBOV-95), EBOV/May (EBOV-76), SUDV, MARV, and RAVV.
Results are from ELISA as described in Materials and Methods. Shown is the Max Effect (in % inhibition) along with the IC50 values (in μM). Vero E6 proliferation shows toxicity of clomiphene on uninfected cells. Results indicate that clomiphene is effective across all native virus strains evaluated. Results are from two or more replicates.