(A and B) Clomiphene (A) and toremifene (B) were tested for their ability to inhibit VLPs with the EBOV GP1,2 glycoprotein (VLP-GP), the VSV-G glycoprotein (VLP-G), and LCMV GP (VLP-LCMV). Results indicate that both clomiphene and toremifene exhibit greater specificity to VLPs bearing the EBOV GP1,2 glycoprotein compared to VLPs bearing VSV-G or the LCMV GP. For each compound, assays with the different VLPs were performed in parallel. Error bars represent the SE for two or more replicates.