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. Author manuscript; available in PMC: 2014 Mar 15.
Published in final edited form as: Sci Transl Med. 2013 Jun 19;5(190):190ra79. doi: 10.1126/scitranslmed.3005471

Fig. 8. Endosomal pH upon exposure to clomiphene and toremifene.

Fig. 8

(A to D) SNB19 cells were preincubated in the presence of (A) DMSO vehicle, (B) 10 mM NH4Cl as a positive control for inhibition of acidification, (C) 5 μM clomiphene, or (D) 0.8 μM toremifene for 1 hour at 37°C. At this time, Lyso-Tracker Red (± inhibitor, as indicated) was added, and the cells were incubated for an additional 30 min at 37°C. At this time, the cells were fixed, viewed, and photographed with a confocal microscope. Images are representative of 10 fields observed per condition.