. Author manuscript; available in PMC: 2014 Mar 15.

Published in final edited form as: Sci Transl Med. 2013 Jun 19;5(190):190ra79. doi: 10.1126/scitranslmed.3005471

Table 1. Activity of clomiphene and toremifene across native filovirus strains.

IC₅₀, the concentration at which 50% inhibition of viral infection was observed; Max effect, the maximum percent inhibition observed.

Compound	EBOV/Kik		EBOV/May		SUDV		MARV		RAVV
Compound	IC₅₀ (μM)	Max effect	IC₅₀ (μM)	Max effect	IC₅₀ (μM)	Max effect	IC₅₀ (μM)	Max effect	IC₅₀ (μM)	Max effect
Clomiphene	11.1	89.4	3.83	97.8	4.96	97.6	5.82	97.0	7.18	96.0
Toremifene	1.73	96.6	0.973	3.83	3.96	97.8	5.73	95.7	6.17	95.6